Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.

The Biochemical journal - 15 Oct 2004

Molotkov Andrei, Ghyselinck Norbert B, Chambon Pierre, Duester Gregg

Abstract excerpt

Vitamin A homoeostasis requires the gene encoding cellular retinol-binding protein-1 (Crbp1) which stimulates conversion of retinol into retinyl esters that serve as a storage form of vitamin A. The gene encoding alcohol dehydrogenase-1 (Adh1) greatly facilitates degradative metabolism of excess retinol into retinoic acid to protect against toxic effects of high dietary vitamin A. Crbp1-/-/Adh1-/- double mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esterification

Share to Homeostasis

Share to Mice, Knockout

Share to Retinol-Binding Proteins

Share to Vitamin A

Source

Open in PubMed Open full text

Identifiers

PMID: 15193143
DOI: 10.1042/BJ20040621
PMCID: PMC1134070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.PMID 15193143Read ↗

Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.Semantic proximity Read ↗

Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.Semantic proximity Read ↗

Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases.Semantic proximity Read ↗

Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.Semantic proximity Read ↗

Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3.Semantic proximity Read ↗

RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse EmbryogenesisSemantic proximity Read ↗

Contribution of cellular retinol‐binding protein type 1 to retinol metabolism during mouse developmentSemantic proximity Read ↗

Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice.Semantic proximity Read ↗

The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.Semantic proximity Read ↗

Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).Semantic proximity Read ↗

Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation.Semantic proximity Read ↗

Cold-mediated regulation of systemic retinol transport controls adipose tissue browningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.