Article

Bioinformatic Validation and Phytochemical Targeting of the TPX2–Aurora A Axis in Breast Cancer: An Integrated In Silico Study

2026-08-20

Abstract excerpt

TPX2, a spindle assembly factor encoded by the TPX2 gene, plays a pivotal role in tumor progression and cellular transformation. Overexpression of TPX2 has been widely documented across multiple malignancies, including breast cancer, and is associated with poor clinical outcomes, including increased metastasis, recurrence, and poor prognosis. Functional studies using TPX2-specific siRNA have demonstrated its criti...

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Literature Corpus work: cabf50dc-b5b3-5da0-b660-0e1fceb93e59
DOI: 10.20944/preprints202608.1384.v1

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