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Article

Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies.

Nucleic acids research - 1 Jan 2005

Piron Maria, Beguiristain Nerea, Nadal Anna, Martínez-Salas Encarnación, Gómez Jordi

Abstract excerpt

Hepatitis C virus (HCV) RNA is recognized and cleaved in vitro by RNase P enzyme near the AUG start codon. Because RNase P identifies transfer RNA (tRNA) precursors, it has been proposed that HCV RNA adopts structural similarities to tRNA. Here, we present experimental evidence of RNase P sensitivity conservation in natural RNA variant sequences, including a mutant sequence (A368-G) selected in vitro because it...

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Identifiers

PMID: 15755750
DOI: 10.1093/nar/gki290
PMCID: PMC1062876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies.PMID 15755750Read ↗

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