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Article

Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23

13 Dec 2021

Abstract excerpt

Significance Herpes simplex viruses (HSV) can switch between lytic and latent infections, which are lifelong sources of recurrent diseases. In this process, the immediate early protein ICP0 crucially drives herpesvirus gene expression or reactivation from latency. The regulatory network of ICP0 expression is, however, largely obscure. We uncover that the HSV-1 virulence factor γ 1 34.5 interacts with and...

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PMID: 34903664
DOI: 10.1073/pnas.2113060118

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