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Article

Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.

Journal of virology - 1 Oct 2010

van Lint Allison L, Murawski Matthew R, Goodbody Rory E, Severa Martina, Fitzgerald Katherine A, Finberg Robert W, Knipe David M, Kurt-Jones Evelyn A

Abstract excerpt

The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host responses to infection raised attention to the complex interplay between viral gene products and the host innate immune responses in determining the outcome of virus infection. Robust inflammatory cytokine responses are observed in herpes simplex virus (HSV)-infected animals and cells. Our studies have demonstrated that...

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Source

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Identifiers

PMID: 20686034
DOI: 10.1128/JVI.00063-10
PMCID: PMC2950559

Genes

TLR2
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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