Article

In HSV-1, the LAT Enhancer Drives Pre-IE VP16 Transcription to Initiate Reactivation

2026-01-06

Abstract excerpt

The HSV-1 VP16 protein, delivered to the nuclei of epithelial cells from the tegument layer of infecting virions, drives viral Immediate-Early (IE) transcription to initiate productive (lytic) infection. Latent HSV-1, established in sensory neurons, reactivates to a lytic infection in the absence of a recent de novo infection event that would deliver tegument proteins like VP16. Therefore, the role of the protein...

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Literature Corpus work: a9cbac34-b663-59a1-87ab-e23e203b7852
DOI: 10.64898/2026.01.06.697999

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