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Article

Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates.

Current drug metabolism - 1 Jan 2008

Sorich Michael J, Smith Paul A, Miners John O, Mackenzie Peter I, McKinnon Ross A

Abstract excerpt

UDP glucurononosyltransferases (UGT) are a superfamily of enzymes that catalyse the conjugation of a range of structurally diverse drugs, environmental and endogenous chemicals with glucuronic acid. This process plays a significant role in the clearance and detoxification of many chemicals. Over the last decade the regulation and substrate profiles of UGT isoforms have been increasingly characterised. The...

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PMID: 18220572
DOI: 10.2174/138920008783331167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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