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Article

The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Wakutani Yosuke, Kowa Hisanori, Kusumi Masayoshi, Nakaso Kazuhiro, Isoe-Wada Kenji, Yano Hidetaka, Urakami Katsuya, Takeshima Takao, Nakashima Kenji

Abstract excerpt

Recent epidemiological studies have emphasized the impact of elevated blood homocysteine levels on the pathogenesis of Alzheimer's disease (AD). In spite of a significant impact of a MTHFR C677T polymorphism on the blood homocysteine levels, the association between the C677T polymorphism and AD remains controversial. Therefore, other unidentified genetic factor(s) that regulate blood homocysteine levels may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 14739536
DOI: 10.1159/000076348

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimer's disease.PMID 14739536Read ↗

Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms.Semantic proximity Read ↗

The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease.Semantic proximity Read ↗

The MTHFR 677T allele may influence the severity and biochemical risk factors of Alzheimer's disease in an Egyptian population.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T and A1298C genetic polymorphisms and plasma homocysteine in Alzheimer's disease in an Algerian population.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease.Semantic proximity Read ↗

Genetic influence of plasma homocysteine on Alzheimer's disease.Semantic proximity Read ↗

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A pilot study evaluating the contribution of SLC19A1 (RFC-1) 80G>a polymorphism to Alzheimer's disease in Italian Caucasians.Semantic proximity Read ↗

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Relationship of homocysteine and gene polymorphisms of its related metabolic enzymes with Alzheimer's disease.Semantic proximity Read ↗

Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.Semantic proximity Read ↗

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