Article
Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2009
Helisalmi Seppo, Väkevä Antti, Hiltunen Mikko, Soininen Hilkka
Abstract excerpt
BACKGROUND: In the present study we determined whether the cystatin c gene (CST3) is genetically associated with late-onset Alzheimer's disease (AD). METHODS: Two informative flanking single nucleotide polymorphisms (SNP), rs2424577 and rs3827143, of the CST3 gene and apolipoprotein E (APOE) gene were assessed in 568 Finnish AD patients and 688 cognitively healthy controls. Samples were genotyped with the TaqMan...
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