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Article

Genetic influence of plasma homocysteine on Alzheimer's disease.

Neurobiology of aging - 1 Feb 2018

Roostaei Tina, Felsky Daniel, Nazeri Arash, De Jager Philip L, Schneider Julie A, Bennett David A, Voineskos Aristotle N

Abstract excerpt

Observational studies have consistently reported elevated plasma homocysteine as a risk factor for Alzheimer's disease (AD). However, results from clinical trials of homocysteine-lowering treatments are inconsistent. This discrepancy may be explained by a lack of causal association between homocysteine and AD. Mendelian randomization studies have the potential to provide insight into the causality of this...

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Identifiers

PMID: 29102475
DOI: 10.1016/j.neurobiolaging.2017.09.033
PMCID: PMC6953632

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