Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.

The Journal of biological chemistry - 23 Apr 2004

Zilberberg Alona, Yaniv Abraham, Gazit Arnona

Abstract excerpt

Members of the low density lipoprotein receptor family (LDLR), LRP5/6, were shown to interact with the Frizzled (Fz) receptors and to function as Wnt coreceptors. Here we show that mLRP4T100, a minireceptor of LRP1, another member of the LDLR family, interacts with the human Fz-1 (HFz1), previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Frizzled Receptors
Share to Low Density Lipoprotein Receptor-Related Protein-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Receptors, Neurotransmitter

Share to Wnt Proteins

Share to Wnt3 Protein

Share to Wnt3A Protein

Source

Identifiers

PMID: 14739301
DOI: 10.1074/jbc.M311292200

Genes

LRP1
LDLR
LRP5
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14739301-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.PMID 14739301Read ↗

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasisSemantic proximity Read ↗

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.Semantic proximity Read ↗

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family membersSemantic proximity Read ↗

The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade.Semantic proximity Read ↗

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.Semantic proximity Read ↗

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.Semantic proximity Read ↗

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.Semantic proximity Read ↗

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.Semantic proximity Read ↗

The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate.Semantic proximity Read ↗

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.Semantic proximity Read ↗

LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.Semantic proximity Read ↗

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.