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Article

LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.

Circulation research - 17 Aug 2012

Pi Xinchun, Schmitt Christopher E, Xie Liang, Portbury Andrea L, Wu Yaxu, Lockyer Pamela, Dyer Laura A, Moser Martin, Bu Guojun, Flynn Edward J, Jin Suk-Won, Patterson Cam

Abstract excerpt

RATIONALE: Among the extracellular modulators of Bmp (bone morphogenetic protein) signaling, Bmper (Bmp endothelial cell precursor-derived regulator) both enhances and inhibits Bmp signaling. Recently we found that Bmper modulates Bmp4 activity via a concentration-dependent, endocytic trap-and-sink mechanism. OBJECTIVE: To investigate the molecular mechanisms required for endocytosis of the Bmper/Bmp4 and...

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Topics

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Share to Bone Morphogenetic Protein 4
Share to Bone Morphogenetic Protein Receptors, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to Endothelial Cells

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Neovascularization, Physiologic

Share to Receptors, LDL

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22777006
DOI: 10.1161/CIRCRESAHA.112.274597
PMCID: PMC3495066

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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