Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.

Molecular and cellular biology - 1 Jun 2012

Carmon Kendra S, Lin Qiushi, Gong Xing, Thomas Anthony, Liu Qingyun

Abstract excerpt

LGR5, a seven-transmembrane domain receptor of the rhodopsin family, is a Wnt target gene and a bona fide marker of adult stem cells in the gastrointestinal tract and hair follicle bulge. Recently, we and others demonstrated that LGR5 and its homologues function as receptors of the R-spondin family of stem cell factors to potentiate Wnt/β-catenin signaling. However, the mechanism of how LGR5 enhances the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Endocytosis
Share to Frizzled Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Receptors, G-Protein-Coupled

Share to Thrombospondins

Share to Wnt Signaling Pathway

Share to Wnt3A Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22473993
DOI: 10.1128/MCB.00272-12
PMCID: PMC3372227

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.PMID 22473993Read ↗

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.Semantic proximity Read ↗

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retinaSemantic proximity Read ↗

LGR4 and LGR5 Function Redundantly During Human Endoderm DifferentiationSemantic proximity Read ↗

The structural basis of R-spondin recognition by LGR5 and RNF43.Semantic proximity Read ↗

Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse.Semantic proximity Read ↗

Structural basis for R-spondin recognition by LGR4/5/6 receptors.Semantic proximity Read ↗

The Wnt Signaling Receptor Lrp5 Is Required for Mammary Ductal Stem Cell Activity and Wnt1-induced TumorigenesisSemantic proximity Read ↗

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.Semantic proximity Read ↗

Kekkon5 is an extracellular regulator of BMP signaling.Semantic proximity Read ↗

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.Semantic proximity Read ↗

The function of endocytosis in Wnt signalingSemantic proximity Read ↗

The R-spondin protein family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.