Article
Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.
Blood - 1 May 2004
Li Tong-Tong, Larrucea Susana, Souza Shiloe, Leal Suzanne M, López José A, Rubin Edward M, Nieswandt Bernhard, Bray Paul F
Abstract excerpt
As mouse models have become commonplace for studying hemostasis and thrombosis, we considered whether the mouse system had utility for assessing genetic alterations in platelet receptors. Platelets from 5 mouse strains (C57BL/6 [C57], FVB/N [FVB], BALB/c, C3H/He, and 129Sv) showed only minor differences in the expression of integrin alpha(IIb), integrin beta(3), glycoprotein (GP) Ib alpha, or GPVI across strains....
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