Article

Identification of Regulatory Loci for Megakaryocyte and Hepatocyte Coagulation Factor V Expression in Mice

2025-08-19

Abstract excerpt

<h4>Background</h4> Factor V (FV) plays a central role in the coagulation cascade, acting in both a procoagulant and anticoagulant manner. The majority of FV is produced by the liver hepatocytes. In humans, FV is endocytosed by megakaryocytes, whereas in mice, FV is synthesized by megakaryocytes. Little is known about the genomic factors regulating FV transcription in humans and mice. <h4>Objective</h4> To inves...

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Literature Corpus work: 68d78673-e181-55d1-9082-0bafbeff943a
DOI: 10.1101/2025.08.14.670312

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