Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections

Abstract excerpt

mice before BCG infection prevented manifestations of severe BCG disease and maintained lung and spleen organ integrity, which was accompanied by a reduced mycobacterial burden in lung and spleen and a prolonged overall survival in animals that received a transplant. In summary, we demonstrate an HSC-based gene therapy approach for IFNγR1 deficiency, which protects mice from severe mycobacterial infections,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Cell Function and Interaction
• Share to Viral gastroenteritis research and epidemiology
• Share to Virus-based gene therapy research