Article
Inherent bias toward the null hypothesis in conventional multipoint nonparametric linkage analysis.
American journal of human genetics - 1 Feb 2004
Schork Nicholas J, Greenwood Tiffany A
Abstract excerpt
Traditional nonparametric "multipoint" statistical procedures have been developed for assigning allele-sharing values at a locus of interest to pairs of relatives for linkage studies. These procedures attempt to accommodate a lack of informativity, nongenotyped loci, missing data, and related issues concerning the genetic markers used in a linkage study. However, such procedures often cannot overcome these...
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