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Article

Linkage analysis of alcohol dependence using both affected and discordant sib pairs.

BMC genetics - 30 Dec 2005

Shih Pei-Ying, Wang Tao, Xing Chao, Sinha Moumita, Song Yeunjoo, Elston Robert C

Abstract excerpt

The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs. The test depends on an assumed Mendelian control distribution of the number of marker alleles shared identical by descent (IBD), i.e., 1/4, 1/2, and 1/4 for 2, 1, and 0 allele(s) IBD, respectively. However, Mendelian transmission may not always...

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PMID: 16451646
DOI: 10.1186/1471-2156-6-S1-S36
PMCID: PMC1866749

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