Article
Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism.
Biochemistry - 20 Mar 2001
Park D S, Razani B, Lasorella A, Schreiber-Agus N, Pestell R G, Iavarone A, Lisanti M P
Abstract excerpt
The c-Myc oncoprotein contributes to oncogenesis by activating and repressing a repertoire of genes involved in cellular proliferation, metabolism, and apoptosis. Increasing evidence suggests that the repressor function of c-Myc is critical for transformation. Therefore, identifying and characterizing Myc-repressed genes is imperative to understanding the mechanisms of Myc-induced tumorigenesis. Here, we employ...
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