Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential activity of conditional MYC and its variant MYC-S in human mortal fibroblasts.

Oncogene - 26 Oct 2000

Hirst S K, Grandori C

Abstract excerpt

We have explored the effects of the conditional MYC-estrogen receptor fusion protein, MYC-ERTM, in human mortal fibroblasts, WI38, on cell-cycle entry, apoptosis and gene expression. The results indicate that activation of MYC-ERTM in WI38 cells is sufficient to cause S phase entry of quiescent cells, which is preceded by phosphorylation of Rb and activation of the Cdk2-associated kinase. We also analysed the MYC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2-CDC28 Kinases
Share to Cyclin-Dependent Kinase 2
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helix-Loop-Helix Motifs

Share to Leucine Zippers

Share to Proto-Oncogene Proteins c-myc

Share to Retinoblastoma Protein

Share to S Phase

Source

Identifiers

PMID: 11064456
DOI: 10.1038/sj.onc.1203904

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential activity of conditional MYC and its variant MYC-S in human mortal fibroblasts.PMID 11064456Read ↗

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.Semantic proximity Read ↗

Myc’s secret life without MaxSemantic proximity Read ↗

Identification of Downstream-Initiated c-Myc Proteins Which Are Dominant-Negative Inhibitors of Transactivation by Full-Length c-Myc ProteinsSemantic proximity Read ↗

Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster.Semantic proximity Read ↗

Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells.Semantic proximity Read ↗

Sustained loss of a neoplastic phenotype by brief inactivation of MYC.Semantic proximity Read ↗

Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism.Semantic proximity Read ↗

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.Semantic proximity Read ↗

Differential modulation of cyclin gene expression by MYC.Semantic proximity Read ↗

Overexpression of c-Myc Alters G 1 /S Arrest following Ionizing RadiationSemantic proximity Read ↗

Differential Subcellular Distribution of Mortalin in Mortal and Immortal Mouse and Human FibroblastsSemantic proximity Read ↗

The Myc Negative Autoregulation Mechanism Requires Myc-Max Association and Involves the c- myc P2 Minimal PromoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.