Cobalt Enhances DNA Cleavage Mediated by Human Topoisomerase IIα <i>in Vitro</i> and in Cultured Cells

Abstract excerpt

Although cobalt is an essential trace element for humans, the metal is genotoxic and mutagenic at higher concentrations. Treatment of cells with cobalt generates DNA strand breaks and covalent protein-DNA complexes. However, the basis for these effects is not well understood. Since the toxic events induced by cobalt resemble those of topoisomerase II poisons, the effect of the metal on human topoisomerase IIalpha...

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