Article
New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk.
Regulatory toxicology and pharmacology : RTP - 1 Oct 2015
Kirkland David, Brock Tom, Haddouk Hasnaà, Hargeaves Victoria, Lloyd Melvyn, Mc Garry Sarah, Proudlock Raymond, Sarlang Séverine, Sewald Katherina, Sire Guillaume, Sokolowski Andrea, Ziemann Christina
Abstract excerpt
The genotoxicity of cobalt metal and cobalt compounds has been widely studied. Several publications show induction of chromosomal aberrations, micronuclei or DNA damage in mammalian cells in vitro in the absence of S9. Mixed results were seen in gene mutation studies in bacteria and mammalian cells in vitro, and in chromosomal aberration or micronucleus assays in vivo. To resolve these inconsistencies, new...
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