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<i>N</i>-Acetyl-<i>p</i>-benzoquinone Imine, the Toxic Metabolite of Acetaminophen, Is a Topoisomerase II Poison

1 Mar 2004

Abstract excerpt

Although acetaminophen is the most widely used analgesic in the world, it is also a leading cause of toxic drug overdoses. Beyond normal therapeutic doses, the drug is hepatotoxic and genotoxic. All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Since many of the cytotoxic/genotoxic events triggered by NAPQI are...

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PMID: 15035644
DOI: 10.1021/bi036107r

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