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Article

Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.

Journal of bacteriology - 1 Aug 2009

Liu I-Fen, Annamalai Thirunavukkarasu, Sutherland Jeanette H, Tse-Dinh Yuk-Ching

Abstract excerpt

Escherichia coli expressing SOS-inducing mutant topoisomerase I was utilized to demonstrate that covalent protein-DNA complex accumulation results in oxidative damage. Hydroxyl radicals were detected following mutant topoisomerase induction. The presence of the Fe(2+) chelator 2,2'-dipyridyl and an iscS mutation affecting Fe-S cluster formation protect against topoisomerase I cleavage complex-mediated cell killing.

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Identifiers

PMID: 19525344
DOI: 10.1128/JB.00559-09
PMCID: PMC2725605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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