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1,4-Benzoquinone Is a Topoisomerase II Poison

21 May 2004

Abstract excerpt

Benzene is a human carcinogen that induces hematopoietic malignancies. It is believed that benzene does not initiate leukemias directly, but rather generates DNA damage through a series of phenolic metabolites, especially 1,4-benzoquinone. The cellular consequences of 1,4-benzoquinone are consistent with those of topoisomerase II-targeted drugs. Therefore, it has been proposed that the compound initiates specific...

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PMID: 15182198
DOI: 10.1021/bi049756r

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