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Article

Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.

Diabetologia - 1 Mar 2004

Doney A S F, Fischer B, Cecil J E, Boylan K, McGuigan F E, Ralston S H, Morris A D, Palmer C N A

Abstract excerpt

AIMS/HYPOTHESIS: The Pro12Ala polymorphism of peroxisome proliferator-activated receptor (PPAR)gamma has been consistently associated with Type 2 diabetes. The rare Ala12 variant is estimated to reduce the risk of developing Type 2 diabetes by 20 percent. This variant is in linkage disequilibrium with another common variant, T1431. Both have opposing associations with body weight. We therefore examined the...

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Source

Identifiers

PMID: 14730381
DOI: 10.1007/s00125-003-1323-1

Genes

PPARG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.PMID 14730381Read ↗

Association of the Pro12Ala and C1431T variants of PPARgamma and their haplotypes with susceptibility to gestational diabetes.Semantic proximity Read ↗

Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.Semantic proximity Read ↗

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.Semantic proximity Read ↗

Association of the peroxisome proliferator-activated receptor-gamma2 Pro12Ala but not the C1431T gene variants with lower body mass index in Type 2 diabetes.Semantic proximity Read ↗

Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.Semantic proximity Read ↗

Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes.Semantic proximity Read ↗

Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population.Semantic proximity Read ↗

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.Semantic proximity Read ↗

The association between the Pro12Ala variant in the PPARγ2 gene and type 2 diabetes mellitus and obesity in a Chinese population.Semantic proximity Read ↗

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.Semantic proximity Read ↗

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population.Semantic proximity Read ↗

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.Semantic proximity Read ↗

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