Article
Association of the peroxisome proliferator-activated receptor-gamma2 Pro12Ala but not the C1431T gene variants with lower body mass index in Type 2 diabetes.
Journal of endocrinological investigation - 1 Dec 2007
Mohamed M Ben Hadj, Mtiraoui N, Ezzidi I, Chaieb M, Mahjoub T, Almawi W Y
Abstract excerpt
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor involved in lipid metabolism, adipocyte differentiation and regulation of insulin sensitivity, and is associated with Type 2 diabetes (T2DM). The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory...
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