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Article

Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.

BMC genetics - 13 Nov 2002

Doney Alex, Fischer Bettina, Frew David, Cumming Alastair, Flavell David M, World Michael, Montgomery Hugh E, Boyle Douglas, Morris Andrew, Palmer Colin N A

Abstract excerpt

BACKGROUND: Variation at the PPARG locus may influence susceptibility to type 2 diabetes and related traits. The Pro12Ala polymorphism may modulate receptor activity and is associated with protection from type 2 diabetes. However, there have been inconsistent reports of its association with obesity. The silent C1431T polymorphism has not been as extensively studied, but the rare T allele has also been...

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Identifiers

PMID: 12429071
DOI: 10.1186/1471-2156-3-21
PMCID: PMC137581

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.PMID 12429071Read ↗

Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.Semantic proximity Read ↗

Association of the peroxisome proliferator-activated receptor-gamma2 Pro12Ala but not the C1431T gene variants with lower body mass index in Type 2 diabetes.Semantic proximity Read ↗

Association of the Pro12Ala and C1431T variants of PPARgamma and their haplotypes with susceptibility to gestational diabetes.Semantic proximity Read ↗

Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.Semantic proximity Read ↗

Associations between C1431T and Pro12Ala variants of PPARγ gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population.Semantic proximity Read ↗

Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population.Semantic proximity Read ↗

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.Semantic proximity Read ↗

Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes.Semantic proximity Read ↗

Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study.Semantic proximity Read ↗

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.Semantic proximity Read ↗

The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men.Semantic proximity Read ↗

Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study.Semantic proximity Read ↗

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