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Article

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit

13 Aug 2008

Abstract excerpt

The stem cell factor receptor/c-Kit plays an important physiological role in hematopoiesis, melanogenesis, and gametogenesis. It has also been implicated in numerous human malignancies. Signal transduction pathways shown to be of importance for c-Kit-mediated transformation include the phosphoinositide 3-kinase (PI3K)/Akt pathway. We have previously shown that two alternative splice forms of c-Kit, denoted...

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PMID: 18697750
DOI: 10.1074/jbc.m709703200

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Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-KitPMID 18697750Read ↗

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Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.Semantic proximity Read ↗

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