Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of Acetaminophen-Induced Apoptosis in Cultured Cells: Roles of Caspase-3, DNA Fragmentation Factor, and the Ca2+ and Mg2+ Endonuclease DNAS1L3

1 Jan 2004

Abstract excerpt

We have recently shown that acetaminophen induces many of the apoptotic traits in hepatoma cells and lymphocytes (Boulares et al. (2002d). In an effort to further investigate the mechanism by which non-metabolized acetaminophen induces apoptosis, we have now examined the roles of caspase-3, the DNA fragmentation factor, and the poly(ADP-ribose) polymerase-1-regulated Ca2+ and Mg2+-dependent endonuclease DNAS1L3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Drug-Induced Hepatotoxicity and Protection
Share to Hepatitis B Virus Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14725611
DOI: 10.1111/j.1742-7843.2004.pto940105.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of Acetaminophen-Induced Apoptosis in Cultured Cells: Roles of Caspase-3, DNA Fragmentation Factor, and the Ca2+ and Mg2+ Endonuclease DNAS1L3PMID 14725611Read ↗

The multiple mechanisms and modes of cell death after acetaminophen overdoseSemantic proximity Read ↗

Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells.Semantic proximity Read ↗

Neurotoxic Effects of Alcohol and Acetaldehyde During Embryonic DevelopmentSemantic proximity Read ↗

Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cellsSemantic proximity Read ↗

Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.Semantic proximity Read ↗

Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation.Semantic proximity Read ↗

Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.Semantic proximity Read ↗

<i>N</i>-Acetyl-<i>p</i>-benzoquinone Imine, the Toxic Metabolite of Acetaminophen, Is a Topoisomerase II PoisonSemantic proximity Read ↗

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.Semantic proximity Read ↗

Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.Semantic proximity Read ↗

Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cellsSemantic proximity Read ↗

Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.