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Article

Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.

DNA repair - 1 Aug 2007

Hansen Ryan J, Ludeman Susan M, Paikoff Sari J, Pegg Anthony E, Dolan M Eileen

Abstract excerpt

O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that protects cells from the biological consequences of alkylating agents by removing alkyl groups from the O(6)-position of guanine. Cyclophosphamide and ifosfamide are oxazaphosphorines used clinically to treat a wide variety of cancers; however, the role of MGMT in recognizing DNA damage induced by these agents is unclear. In vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17485251
DOI: 10.1016/j.dnarep.2007.03.010
PMCID: PMC1989758

Genes

MGMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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