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Article

Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.

Experimental cell research - 15 Sept 1996

Shao R G, Shimizu T, Pommier Y

Abstract excerpt

Brefeldin A (BFA) is a natural product that affects the structure and function of the Golgi apparatus and is in development for cancer chemotherapy. We observed that a wide range of cancer cells could undergo DNA fragmentation associated with apoptosis after BFA treatment. This DNA fragmentation was induced within 15 h in HL60 leukemia cells and after 48 h in K562 leukemia and HT-29 colon carcinoma cells with BFA...

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Identifiers

PMID: 8831555
DOI: 10.1006/excr.1996.0266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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