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Article

Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.

Journal of cellular biochemistry - 1 Mar 2000

Du J, Suzuki H, Nagase F, Akhand A A, Yokoyama T, Miyata T, Kurokawa K, Nakashima I

Abstract excerpt

Methylglyoxal (MG) is a physiological metabolite, but it is known to be toxic, inducing stress in cells and causing apoptosis. This study examines molecular mechanisms in the MG-induced signal transduction leading to apoptosis, focusing particularly on the role of JNK activation. We first confirmed that MG caused apoptosis in Jurkat cells and that it was cell type dependent because it failed to induce apoptosis...

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Identifiers

PMID: 10723098
DOI: 10.1002/(sici)1097-4644(20000501)77:2<333::aid-jcb15>3.0.co;2-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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