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Article

Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cells

7 Jun 2019

Abstract excerpt

Fluoxetine has been shown to induce anti-tumour activity. The aim of this study was to determine the effect of fluoxetine on HCT116+/+ and p53 gene-depleted HCT116-/- human colorectal cancer cells and the mechanisms, including potential p53-dependence, of its action. Fluoxetine-induced apoptosis was investigated by mitochondrial membrane potential assay, Annexin V assay, two-step cell cycle analysis using...

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Identifiers

PMID: 31181210
DOI: 10.1016/j.ejphar.2019.172441

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