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<i>In silico</i> dissection of cell-type-associated patterns of gene expression in prostate cancer

13 Jan 2004

Abstract excerpt

Prostate tumors are complex entities composed of malignant cells mixed and interacting with nonmalignant cells. However, molecular analyses by standard gene expression profiling are limited because spatial information and nontumor cell types are lost in sample preparation. We scored 88 prostate specimens for relative content of tumor, benign hyperplastic epithelium, stroma, and dilated cystic glands. The...

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PMID: 14722351
DOI: 10.1073/pnas.2536479100

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