Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer.

doi:10.1158/1541-7786.MCR-05-0098

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Article

Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer.

Molecular cancer research : MCR - 1 Feb 2006

Nanni Simona, Priolo Carmen, Grasselli Annalisa, D'Eletto Manuela, Merola Roberta, Moretti Fabiola, Gallucci Michele, De Carli Piero, Sentinelli Steno, Cianciulli Anna Maria, Mottolese Marcella, Carlini Paolo, Arcelli Diego, Helmer-Citterich Mauro, Gaetano Carlo, Loda Massimo, Pontecorvi Alfredo, Bacchetti Silvia, Sacchi Ada, Farsetti Antonella

Abstract excerpt

The histopathologic and molecular heterogeneity of prostate cancer and the limited availability of human tumor tissue make unraveling the mechanisms of prostate carcinogenesis a challenging task. Our goal was to develop an ex vivo model that could be reliably used to define a prognostic signature based on gene expression profiling of cell cultures that maintained the tumor phenotype. To this end, we derived...

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PMID: 16513839
DOI: 10.1158/1541-7786.MCR-05-0098

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