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Article

Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype

26 Apr 2021

Abstract excerpt

BACKGROUND AND OBJECTIVES: Transcriptomic landscape of prostate cancer (PCa) shows multidimensional variability, potentially arising from the cell-of-origin, reflected in serum markers, and most importantly related to drug sensitivities. For example, Aggressive Variant Prostate Cancer (AVPC) presents low PSA per tumor burden, and characterized by de novo resistance to androgen receptor signaling inhibitors...

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PMID: 33903734
DOI: 10.1038/s41391-021-00364-x

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