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Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor Microenvironment Associated with Clinicopathologic Phenotypes

25 Jan 2012

Abstract excerpt

PURPOSE: Recent studies suggest that tumor microenvironment (stroma) is important in carcinogenesis and progression. We sought to integrate global genomic structural and expressional alterations in prostate cancer epithelium and stroma and their association with clinicopathologic features. EXPERIMENTAL DESIGN: We conducted a genome-wide LOH/allelic imbalance (AI) scan of DNA from epithelium and stroma of 116...

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PMID: 22275508
DOI: 10.1158/1078-0432.ccr-11-2535

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