Article
The intracellular plasma membrane-connected compartment in the assembly of HIV-1 in human macrophages.
BMC biology - 23 Jun 2016
Nkwe David O, Pelchen-Matthews Annegret, Burden Jemima J, Collinson Lucy M, Marsh Mark
Abstract excerpt
BACKGROUND: In HIV-infected macrophages, newly formed progeny virus particles accumulate in intracellular plasma membrane-connected compartments (IPMCs). Although the virus is usually seen in these compartments, it is unclear whether HIV assembly is specifically targeted to IPMCs or whether some viruses may also form at the cell surface but are not detected, as particles budding from the latter site will be...
Topics
- Cell Compartmentation
- Cell Membrane
- Cryoelectron Microscopy
- HEK293 Cells
- HIV-1
- Humans
- Imaging, Three-Dimensional
- Intracellular Space
- Macrophages
- Monocytes
- Mutation