Article
Essential and supporting host cell factors for HIV-1 budding
1 Oct 2011
Abstract excerpt
HIV-1 employs its structural proteins to orchestrate assembly and budding at the plasma membrane of host cells. The Gag polyprotein is sufficient to form virus-like particles in the absence of other viral proteins and provides a platform to interact with numerous cellular factors that regulate Gag trafficking to the site of assembly and budding. Notably endosomal sorting complexes required for transport have...