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Visualization of Retroviral Replication in Living Cells Reveals Budding into Multivesicular Bodies

1 Sept 2003

Abstract excerpt

Retroviral assembly and budding is driven by the Gag polyprotein and requires the host-derived vacuolar protein sorting (vps) machinery. With the exception of human immunodeficiency virus (HIV)-infected macrophages, current models predict that the vps machinery is recruited by Gag to viral budding sites at the cell surface. However, here we demonstrate that HIV Gag and murine leukemia virus (MLV) Gag also drive...

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PMID: 14617360
DOI: 10.1034/j.1600-0854.2003.00135.x

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