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Article

TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.

Molecular biology of the cell - 1 Apr 2004

Perera David, Perez-Hidalgo Livia, Moens Peter B, Reini Kaarina, Lakin Nicholas, Syväoja Juhani E, San-Segundo Pedro A, Freire Raimundo

Abstract excerpt

Mammalian TopBP1 is a BRCT domain-containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone gamma-H2AX-positive dom...

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Identifiers

PMID: 14718568
DOI: 10.1091/mbc.e03-06-0444
PMCID: PMC379256

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14718568-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.PMID 14718568Read ↗

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.Semantic proximity Read ↗

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalSemantic proximity Read ↗

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.Semantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.Semantic proximity Read ↗

An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Semantic proximity Read ↗

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.Semantic proximity Read ↗

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9Semantic proximity Read ↗

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