Article
Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2004
Summar Marshall L, Gainer James V, Pretorius Mias, Malave Hector, Harris Stephanie, Hall Lynn D, Weisberg Alec, Vaughan Douglas E, Christman Brian W, Brown Nancy J
Abstract excerpt
Endothelial cells can convert l-citrulline to l-arginine, the precursor of nitric oxide. The present study tests the hypothesis that a C-to-A nucleotide transversion (T1405N) in the gene-encoding carbamoyl-phosphate synthetase 1, the enzyme catalyzing the rate-limiting step in l-citrulline format...
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