Article
Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function.
The New England journal of medicine - 14 Jun 2001
Pearson D L, Dawling S, Walsh W F, Haines J L, Christman B W, Bazyk A, Scott N, Summar M L
Abstract excerpt
BACKGROUND: Endogenous production of nitric oxide is vital for the decrease in pulmonary vascular resistance that normally occurs after birth. The precursor of nitric oxide is arginine, a urea-cycle intermediate. We hypothesized that low concentrations of arginine would correlate with the presence of persistent pulmonary hypertension in newborns and that the supply of this precursor would be affected by a...
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