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Article

Polymorphisms in urea cycle enzyme genes are associated with persistent pulmonary hypertension of the newborn.

Pediatric research - 1 Jan 2018

Kaluarachchi Dinushan C, Smith Caitlin J, Klein Jonathan M, Murray Jeffrey C, Dagle John M, Ryckman Kelli K

Abstract excerpt

BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is characterized by elevated pulmonary vascular resistance. Endogenous nitric oxide is critical for regulation of pulmonary vascular resistance. Nitric oxide is generated from L-arginine, supplied by the urea cycle (UC). We hypothesized that polymorphisms in UC enzyme genes and low concentrations of UC intermediates are associated with...

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Identifiers

PMID: 28609431
DOI: 10.1038/pr.2017.143
PMCID: PMC5811332

Genes

CPS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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