Article
ACE genotype and endothelium-dependent vasodilation of conduit arteries and forearm microcirculation in humans.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2001
Arcaro G, Solini A, Monauni T, Cretti A, Brunato B, Lechi A, Fellin R, Caputo M, Cocco C, Bonora E, Muggeo M, Bonadonna R C
Abstract excerpt
The ACE gene is a candidate gene for cardiovascular disease. Endothelial dysfunction is considered an intermediate phenotype in the pathogenesis of hypertension and atherosclerosis. We evaluated the role of ACE gene polymorphism in endothelial function of young healthy humans. We assessed ACE genotype (deletion [D]/insertion [I] polymorphism) in 92 young healthy individuals. In 88 of them, endothelium-dependent...
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