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Article

RAD51C is required for Holliday junction processing in mammalian cells.

Science (New York, N.Y.) - 9 Jan 2004

Liu Yilun, Masson Jean-Yves, Shah Rajvee, O'Regan Paul, West Stephen C

Abstract excerpt

During genetic recombination and the recombinational repair of chromosome breaks, DNA molecules become linked at points of strand exchange. Branch migration and resolution of these crossovers, or Holliday junctions (HJs), complete the recombination process. Here, we show that extracts from cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14716019
DOI: 10.1126/science.1093037

Genes

RAD51
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14716019-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAD51C is required for Holliday junction processing in mammalian cells.PMID 14716019Read ↗

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationSemantic proximity Read ↗

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.Semantic proximity Read ↗

Holliday junctions in the eukaryotic nucleus: resolution in sight?Semantic proximity Read ↗

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.Semantic proximity Read ↗

Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cellsSemantic proximity Read ↗

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic functionSemantic proximity Read ↗

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.Semantic proximity Read ↗

Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase CellsSemantic proximity Read ↗

Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51Semantic proximity Read ↗

Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs.Semantic proximity Read ↗

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