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Article

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.

The Journal of cell biology - 26 Feb 2007

Kuznetsov Sergey, Pellegrini Manuela, Shuda Kristy, Fernandez-Capetillo Oscar, Liu Yilun, Martin Betty K, Burkett Sandra, Southon Eileen, Pati Debananda, Tessarollo Lino, West Stephen C, Donovan Peter J, Nussenzweig Andre, Sharan Shyam K

Abstract excerpt

RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have generated a hypomorphic allele of Rad51c in addition to a null allele. A subset of mice expressing the hypomorphic allele is infertile. This infertility is caused by sexually dimorphic defects in meiotic recombination,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17312021
DOI: 10.1083/jcb.200608130
PMCID: PMC2064017

Genes

RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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