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Article

Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2005

Mori Toshiaki, Nomoto Shuji, Koshikawa Katsumi, Fujii Tsutomu, Sakai Mitsuru, Nishikawa Yoko, Inoue Soichiro, Takeda Shin, Kaneko Tetsuya, Nakao Akimasa

Abstract excerpt

BACKGROUND/AIMS: Alteration in transforming growth factor-beta signaling pathway is one of the main causes of hepatocellular carcinoma (HCC). The human runt-related transcription factor 3 gene (RUNX3) is an important component of this pathway. RUNX3 locus 1p36 is commonly deleted in a variety of human cancers, including HCC. Therefore, we examined genetic and epigenetic alterations of RUNX3 in human HCC. METHODS:...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15780064
DOI: 10.1111/j.1478-3231.2005.1059.x

Genes

RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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