Article
Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells.
Molecular cancer research : MCR - 1 Feb 2004
Huang Yi, Keen Judith C, Hager Erin, Smith Renee, Hacker Amy, Frydman Benjamin, Valasinas Aldonia L, Reddy Venodhar K, Marton Laurence J, Casero Robert A, Davidson Nancy E
Abstract excerpt
Several polyamine analogues have efficacy against a variety of epithelial tumor models including breast cancer. Recently, a novel class of polyamine analogues designated as oligoamines has been developed. Here, we demonstrate that several representative oligoamine compounds inhibit in vitro growth of human breast cancer MDA-MB-435 cells. The activator protein-1 (AP-1) transcriptional factor family members, c-Jun...
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